Vol. 7, Issue 1, Part B (2025)

Background: Chronic urticaria (CU) is a common skin disorder characterized by the recurrent appearance of wheals and/or angioedema lasting more than six weeks. It significantly impacts patients' quality of life due to its chronic and unpredictable nature. Several studies have investigated the association between plasma D-dimer levels and the severity of CU, aiming to elucidate potential biomarkers for disease activity and prognosis. Understanding this correlation could have significant clinical implications, including improved risk stratification, treatment selection, and monitoring of therapeutic response in CU patients.

Objective: To evaluate the relationship between plasma D-Dimer level and the severity of chronic urticaria patients.

Methods: A total of 40 cases with chronic urticaria and 40 healthy controls were included after getting informed written consent. Socio-demographic profile, clinical features, duration, severity of disease and plasma D-dimer were collected in separated case-record form and analyzed by SPSS 26.0

Results: Mean age of Group I was 33.90±11.21 years with male predominance (52.5%). Both groups were statistically similar in terms of age and sex distribution(p>0.05). In Group I, the majority experienced severe symptoms (50.0%), while 32.5% had moderate and 17.5% had mild CU. Significant differences were observed in plasma D-Dimer levels between Group I and Group II, with mean levels of 0.97±1.24 µg/ml and 0.31±0.15 µg/ml, respectively (p<0.001). There is a significant positive correlation between the UAS-7 score and Plasma D-Dimer level (r=+0.472, p= 0.002)

Conclusion: In conclusion, the study revealed significant differences in plasma D- Dimer levels between CU patients and controls, with higher levels observed in CU patients. Within CU patients, plasma D-Dimer levels varied significantly among different disease severity categories, increasing with severity.