Vol. 7, Issue 1, Part A (2025)

Background: Psoriasis is a persistent inflammatory skin disorder that has been linked to metabolic syndrome, a cluster of conditions which increase the risk of cardiovascular disease and diabetes. Individuals with psoriasis often exhibit components of metabolic syndrome, such as obesity, high blood pressure, dyslipidemia and resistance to insulin. This association may be due to shared inflammatory pathways, where the systemic inflammation in psoriasis contributes to the development of metabolic abnormalities. Furthermore, lifestyle factors, such as diet and physical inactivity, can exacerbate both conditions. Understanding this link is crucial for managing patients with psoriasis, as addressing metabolic syndrome may improve overall health outcomes.

Methodology: The study included 90 patients with psoriasis, 46 males and 44 females, their age ranged from 18 – 64 years. They were diagnosed by Consultant Dermatologists at the Dermatology Clinic, Al-Nasiriyah Teaching Hospital, Thiqar, Iraq.The patient and control who attended Al-Nasiriyah Teaching Hospital, Thiqar, Iraq between from January 2023 to the end of June 2023 in Thiqar, Southern Iraq. Tumor necrosis factor –alpha (TNF- α) was measured using an (ELISA). FBG, S.TG, S.HDL-C were also measured using Cobas integra 400 plus.

Results: The frequency of metabolic syndrome was higher in psoriasis patients compared to age-matched healthy controls.

Conclusion: The result of the current study demonstrated that the patients with psoriasis have a higher prevalence of metabolic syndrome than controls which may contribute to the acceleration of atherosclerosis and the components of MetS were significantly higher among overall patients than control.