Vol. 3, Issue 1, Part A (2021)
Serum uric acid and C-reactive protein in psoriasis vulgaris
Mabroka S Elghazal, Gamal A Duweb
Psoriasis is a chronic, recurrent, immune-mediated inflammatory disease, with a recognised genetic predisposition, the primary immune defect appears to be an increase in cell signalling via chemokines and cytokines that act upregulating gene expression, causing keratinocyte hyperproliferation. Modest hyperuricaemia may be found and has been attributed to enhanced epidermopoiesis. CRP is an acute phase reactive protein, known as a systemic inflammatory biomarker, a lot of studies reported increased CRP concentrations in active psoriasis, and identified CRP as a marker for psoriasis severity. The purpose of this study is to determine the serum uric acid levels and CRP in plaque-type psoriasis patients, and to assess any relation between their levels severity of psoriasis disease, and psoriasis arthropathy. Patients and Methods: A total of 123 Libyan patients with plaque type psoriasis with age ranging from 19-75 years. Severity of the disease is estimated by PASI score. Each patient investigated for CRP titer and serum uric acid levels. The data were statistically analyzed using SPSS version 22 programme. Results: Out of 123 patients, 81(66%) were males and 42(34%) were females with mean age of 42.6 years. Hyperuricemia was detected in 7.1% of female patients and in 6.2% of male patients, The difference between mean level of uric acid in male and female highly significant (P value o.ooo1) and was not significant in relation to the disease severity in both genders (p value 0.675,, p. 0.350). The number of patients with arthropathy was 31(25.2%) with arthropathy and there was a significant correlation between hyperuricemia anf arthropathy (p =0.0001). Out of the total patients 29 (23.6%) had positive CRP titer and there is no significance relation between CRP titer and disease severity with p value= 0.341, but the significance correlation between CRP titer and psoriatic arthritis., out of 31 psoriasis patients with arthritis 18(58%) were with negative CRP titer, 13(42%) were with positive CRP titer, and out of 92 psoriasis patients without arthritis 76(82.6%) were with negative CRP titer, and 16(17.4%) were with positive CRP titer, p value=0.011(significant), so CRP titer in psoriasis patients with arthritis considered to be reliable assessment for psoriatic arthropathy. When we correlate CRP titer with serum uric acids levels in psoriasis patients, we found different results in male and female, there is significance relation between the hyperuricemia and high CRP titer in psoriasis male patients with p value = 0.001. Results of the present study thus, confirm that CRP and uric acid levels should be monitored in patients with psoriasis, and that psoriasis and psoriatic arthritis should be treated as a single disease entity with common inflammatory mediators and pathways. Conclusions: Our data suggested that psoriasis vulgaris patients may have high levels of uric acid and positive CRP titres with a significant difference between genders and psoriatic arthritis but not with the disease severity.
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Mabroka S Elghazal, Gamal A Duweb. Serum uric acid and C-reactive protein in psoriasis vulgaris
. Int. J.Dermatol. Sci. 2021;3(1):01-05. DOI: 10.33545/26649772.2021.v3.i1a.17